Cancer Vaccine Publications

Peer-reviewed work from the Hub on cancer vaccines, neo-antigen discovery, targeted mRNA delivery and mRNA manufacture.

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mRNArchitect: sequence design of mRNA medicines.
Budzinska MA, Zardbani M, Michelle PS, Waterhouse J, Leonard TE, Ghodasara A, Lakshman Das S, Chang RY, Chaudhary N, Cheetham SW, Mercer TR, Gunter HM.
bioRxiv. 2025 Aug 26. doi: 10.1101/2024.12.03.626696.
Preprint
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Systemically delivered mRNA-LNPs transfect primary and secondary liver tumors.
Leighton LJ, Gee YJ, Madugalle SU, Victorova M, Carrodus NL, Bridle KR, Howell SA, Liang X, Miller GC, McMillan CLD, Wijesundara DK, Muller DA, Crawford DHG, Mercer TR, Cheetham SW.
Mol Ther Nucleic Acids. 2026 Sep;37(3):102989. doi: 10.1016/j.omtn.2026.102989.
Open access
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Targeted mRNA delivery with bispecific antibodies that tether LNPs to cell surface markers.
Dietmair B, Humphries J, Mercer TR, Thurecht KJ, Howard CB, Cheetham SW.
Mol Ther Nucleic Acids. 2025 Mar 19;36(2):102520.
Free PMC article
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Mind the cap: Detecting degradation impurities in synthetic mRNAs.
Nielsen D, Victorova M, Mercer TR, Cheetham SW.
Mol Ther Nucleic Acids. 2025 Sep 17;36(4):102701.
Free PMC article
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The design, manufacture and LNP formulation of mRNA for research use.
Leighton LJ, Chaudhary N, Tompkins HT, Kulkarni A, Carrodus NL, Budzinska MA, Lakshman Das S, Cheetham SW, Mercer TR.
Nat Protoc. 2025 Dec;20(12):3552-3581.
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Development of a high-affinity anti-ROR1 variable region for broad anti-cancer immunotherapy.
Wong JKM, Lam PY, Coleborn E, Jose J, Alim L, Tu C, Antczak M, Dietmair B, Hagh AG, Noronha L, Cheetham SW, Hooper J, Beavis PA, Merino D, Berthelet J, Aoude LG, McCart-Reed AE, Lakhani S, Simpson PT, Rossi GR, Brooks AJ, Jones ML, Simpson F, Souza-Fonseca-Guimaraes F.
Mol Ther. 2026 Mar 4;34(3):1382-1398.
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Enhancement of anti-sarcoma immunity by NK cells engineered with mRNA for expression of a EphA2-targeted CAR.
Lam PY, Omer N, Wong JKM, Tu C, Alim L, Rossi GR, Victorova M, Tompkins H, Lin CY, Mehdi AM, Choo A, Elliott MR, Coleborn E, Sun J, Mercer T, Vittorio O, Dobson LJ, McLellan AD, Brooks A, Tuong ZK, Cheetham SW, Nicholls W, Souza-Fonseca-Guimaraes F.
Clin Transl Med. 2025 Jan;15(1):e70140.
Free PMC article
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mRNA vaccine quality analysis using RNA sequencing.
Gunter HM, Idrisoglu S, Singh S, Han DJ, Ariens E, Peters JR, Wong T, Cheetham SW, Xu J, Rai SK, Feldman R, Herbert A, Marcellin E, Tropee R, Munro T, Mercer TR.
Nat Commun. 2023 Sep 21;14(1):5663.
Free PMC article
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A scalable, spin-free approach to generate enhanced induced pluripotent stem cell-derived natural killer cells for cancer immunotherapy.
Rossi GR, Sun J, Lin CY, Wong JK, Alim L, Lam PY, Khosrotehrani K, Wolvetang E, Cheetham SW, Derrick EB, Amoako A, Lehner C, Brooks AJ, Beavis PA, Souza-Fonseca-Guimaraes F.
Immunol Cell Biol. 2024 Nov;102(10):924-934.
Graphical abstract
Vasculature organotropism in drug delivery.
Amruta A, Iannotta D, Cheetham SW, Lammers T, Wolfram J.
Adv Drug Deliv Rev. 2023 Oct;201:115054.
Free PMC article Review

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